Vincent Jarlier Selected Research

DNA Gyrase

2/2013	Synthesis of gatifloxacin derivatives and their biological activities against Mycobacterium leprae and Mycobacterium tuberculosis.
8/2010	Structural insights into the quinolone resistance mechanism of Mycobacterium tuberculosis DNA gyrase.
9/2006	First functional characterization of a singly expressed bacterial type II topoisomerase: the enzyme from Mycobacterium tuberculosis.
4/2004	Mycobacterium tuberculosis DNA gyrase: interaction with quinolones and correlation with antimycobacterial drug activity.

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Vincent Jarlier Research Topics

Disease

21	Tuberculosis (Tuberculoses) 01/2020 - 10/2003
12	Infections 08/2019 - 10/2002
9	Buruli Ulcer 01/2020 - 10/2002
8	Leprosy (Hansen's Disease) 01/2020 - 01/2002
3	Multidrug-Resistant Tuberculosis (Drug-Resistant Tuberculosis) 01/2017 - 11/2006
3	Extensively Drug-Resistant Tuberculosis 03/2015 - 08/2010
2	Nontuberculous Mycobacterium Infections 03/2014 - 02/2011
1	Sepsis (Septicemia) 11/2021
1	Septic Shock (Toxic Shock Syndrome) 01/2019
1	Chronic Renal Insufficiency 01/2019
1	Enterobacteriaceae Infections 01/2015
1	Ventilator-Associated Pneumonia 01/2014
1	HIV Infections (HIV Infection) 06/2012
1	Persistent Infection 01/2012
1	Cystic Fibrosis (Mucoviscidosis) 02/2011
1	Inflammation (Inflammations) 01/2009
1	Endophthalmitis (Ophthalmia) 01/2009
1	Body Weight (Weight, Body) 06/2008
1	Human Influenza (Influenza) 10/2006
1	Multibacillary Leprosy 01/2002

Drug/Important Bio-Agent (IBA)

17	Rifampin (Rifampicin)FDA LinkGeneric 01/2020 - 01/2002
9	Pharmaceutical PreparationsIBA 12/2018 - 06/2008
9	FluoroquinolonesIBA 01/2017 - 01/2006
8	Streptomycin (Streptomycin Sulfate)FDA Link 01/2020 - 02/2007
7	bedaquiline (R207910)IBA 01/2020 - 01/2005
6	Clarithromycin (Biaxin)FDA LinkGeneric 01/2020 - 10/2002
6	Moxifloxacin (Avelox)FDA Link 01/2020 - 10/2007
6	Anti-Bacterial Agents (Antibiotics)IBA 08/2019 - 05/2007
6	Isoniazid (Ftivazide)FDA LinkGeneric 06/2012 - 10/2003
5	Amikacin (A.M.K)FDA LinkGeneric 01/2017 - 10/2002
4	DNA GyraseIBA 02/2013 - 04/2004
4	DNA (Deoxyribonucleic Acid)IBA 02/2013 - 09/2006
4	QuinolonesIBA 02/2013 - 04/2004
3	Ofloxacin (Ofloxacine)FDA LinkGeneric 03/2015 - 01/2002
3	Dapsone FDA Link 11/2013 - 01/2006
3	AminoglycosidesIBA 11/2010 - 02/2007
2	Pyrazinamide FDA LinkGeneric 01/2020 - 01/2005
2	rifapentine (Priftin)FDA Link 01/2020 - 06/2008
2	AcidsIBA 01/2015 - 10/2002
2	Meropenem (Merrem)FDA LinkGeneric 01/2014 - 06/2011
2	Imipenem FDA Link 01/2014 - 06/2011
2	EnzymesIBA 09/2012 - 03/2009
2	DiarylquinolinesIBA 09/2009 - 01/2009
1	Methicillin (Metin)FDA Link 11/2021
1	N 30IBA 01/2020
1	Clofazimine (Lamprene)FDA Link 01/2020
1	CreatinineIBA 01/2019
1	Colistin (Coly-Mycin)FDA Link 01/2019
1	Electron Transport Complex III (Coenzyme Q-Cytochrome-c Reductase)IBA 12/2018
1	Levofloxacin (Levaquin)FDA Link 01/2017
1	Kanamycin FDA Link 01/2017
1	Capreomycin (Capastat)FDA Link 01/2017
1	beta-Lactamases (beta-Lactamase)IBA 01/2015
1	Cefoxitin (Cefoxitin Sodium)FDA LinkGeneric 03/2014
1	Doripenem FDA Link 01/2014
1	Third Generation CephalosporinsIBA 12/2013
1	4-hydroxyphenylisopropylarterenol (CC 25)IBA 02/2013
1	VaccinesIBA 02/2012
1	Ertapenem (Invanz)FDA Link 06/2011
1	Carbapenems (Carbapenem Antibiotics)IBA 06/2011
1	Clavulanic Acid (Potassium Clavulanate)FDA LinkGeneric 06/2011
1	Catalytic DNA (Deoxyribozyme)IBA 08/2010
1	Ethambutol (Myambutol)FDA LinkGeneric 05/2010
1	Cyclic PeptidesIBA 05/2010
1	Oseltamivir (Tamiflu)FDA Link 10/2006
1	Dihydropteroate Synthase (Dihydropteroate Synthetase)IBA 01/2006
1	Pipemidic Acid (Palin)IBA 04/2004
1	Gatifloxacin (Zymar)FDA Link 04/2004
1	Proteins (Proteins, Gene)FDA Link 04/2004
1	Nalidixic Acid FDA Link 04/2004
1	sparfloxacin (AT 4140)FDA Link 10/2002

Therapy/Procedure

3	Injections 01/2020 - 06/2009
3	Therapeutics 09/2013 - 01/2009
2	Duration of Therapy 02/2007 - 11/2006
1	Long-Term Care 01/2015
1	Combination Drug Therapy (Combination Chemotherapy) 02/2012
1	Drug Therapy (Chemotherapy) 02/2012
1	Mesotherapy 06/2009
1	Lasers (Laser) 01/2009
1	Chemoprevention 10/2006